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Novel strategies for inhibiting PD-1 pathway-mediated immune suppression while simultaneously delivering activating signals to tumor-reactive T cells

We previously developed cell-based vaccines as therapeutics for metastatic cancers. The vaccines were aimed at activating type I CD4(+)T cells and consisted of tumor cells transfected with genes encoding syngeneic MHC class II and CD80 costimulatory molecules, and lacking the MHC II-associated invar...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Ostrand-Rosenberg, Suzanne, Horn, Lucas A., Alvarez, Juan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558214/
https://ncbi.nlm.nih.gov/pubmed/25792524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-015-1677-5
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