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The Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity()
Programmed Death Ligand 1 (PD-L1, also known as B7 homolog 1 (B7-H1) or CD274) is a major obstacle to anti-tumor immunity because it (i) tolerizes/anergizes tumor-reactive T cells by binding to its receptor PD-1 (CD279); (ii) renders tumor cells resistant to CD8(+) T cell and FasL-mediated lysis; an...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4185425/ https://ncbi.nlm.nih.gov/pubmed/25281753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401572 |
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