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The Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity()

Programmed Death Ligand 1 (PD-L1, also known as B7 homolog 1 (B7-H1) or CD274) is a major obstacle to anti-tumor immunity because it (i) tolerizes/anergizes tumor-reactive T cells by binding to its receptor PD-1 (CD279); (ii) renders tumor cells resistant to CD8(+) T cell and FasL-mediated lysis; an...

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Detalhes bibliográficos
Main Authors: Ostrand-Rosenberg, Suzanne, Horn, Lucas A., Haile, Samuel T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185425/
https://ncbi.nlm.nih.gov/pubmed/25281753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401572
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