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Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology

A two-period, crossover bioavailability study was conducted to evaluate the relative and absolute bioavailability of immediate (IR) and extended-release (XR) lamotrigine formulations under steady-state conditions in elderly patients with epilepsy. On treatment days, each subject's morning dose...

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Dettagli Bibliografici
Pubblicato in:J Clin Pharmacol
Autori principali: Polepally, Akshanth R., Remmel, Rory P., Brundage, Richard C., Leppik, Ilo E., Rarick, John O., Ramsay, R. Eugene, Birnbaum, Angela K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558201/
https://ncbi.nlm.nih.gov/pubmed/25903807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.522
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