Model-based lamotrigine clearance changes during pregnancy: clinical implication

OBJECTIVE: The objective of the study was to characterize changes in the oral clearance (CL/F) of lamotrigine (LTG) over the course of pregnancy and the postpartum period through a model-based approach incorporating clinical characteristics that may influence CL/F, in support of developing clinical...

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Main Authors: Polepally, Akshanth R, Pennell, Page B, Brundage, Richard C, Stowe, Zachary N, Newport, Donald J, Viguera, Adele C, Ritchie, James C, Birnbaum, Angela K
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038031/
https://ncbi.nlm.nih.gov/pubmed/24883336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.29
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