A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media

CHO cell culture high productivity relies on optimized culture medium management under fed-batch or perfused chemostat strategies enabling high cell densities. In this work, a dynamic metabolic model for CHO cells was further developed, calibrated and challenged using datasets obtained under four di...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Robitaille, Julien, Chen, Jingkui, Jolicoeur, Mario
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558054/
https://ncbi.nlm.nih.gov/pubmed/26331955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136815
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