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Decreased body fat, elevated plasma transforming growth factor-β levels, and impaired BMP4-like signaling in biglycan-deficient mice
Biglycan (BGN), a small leucine-rich proteoglycan, binds the pro-fibrotic cytokine TGFβ and inhibits its bioactivity in vitro. Nevertheless, it is controversial whether BGN plays an inhibitory role in vivo. Therefore, the purpose of this study was to evaluate the effect of BGN deficiency on TGFβ act...
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| Publicado no: | Connect Tissue Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4557867/ https://ncbi.nlm.nih.gov/pubmed/22834985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03008207.2012.715700 |
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