AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody–Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML

CD37 is a tetraspanin expressed on malignant B cells. Recently, CD37 has gained interest as a therapeutic target. We developed AGS67E, an antibody–drug conjugate that targets CD37 for the potential treatment of B/T-cell malignancies. It is a fully human monoclonal IgG2 antibody (AGS67C) conjugated,...

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Publicado en:Mol Cancer Ther
Main Authors: Pereira, Daniel S., Guevara, Claudia I., Jin, Liqing, Mbong, Nathan, Verlinsky, Alla, Hsu, Ssucheng J., Aviña, Hector, Karki, Sher, Abad, Joseph D., Yang, Peng, Moon, Sung-Ju, Malik, Faisal, Choi, Michael Y., An, Zili, Morrison, Kendall, Challita-Eid, Pia M., Doñate, Fernando, Joseph, Ingrid B.J., Kipps, Thomas J., Dick, John E., Stover, David R.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557793/
https://ncbi.nlm.nih.gov/pubmed/25934707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0067
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