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Determination of the Rifamycin Antibiotics Rifabutin, Rifampin, Rifapentine and their Major Metabolites in Human Plasma via Simultaneous Extraction Coupled with LC/MS/MS

A novel assay using high pressure liquid chromatography (HPLC) coupled to mass spectrometer (MS) detection was developed and validated for the rifamycin anti-tuberculosis antibiotics rifampicin (RIF), rifabutin (RBT), rifapentine (RPT) and their active desacetyl metabolites (dRIF, dRBT and dRPT, res...

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Bibliografski detalji
Izdano u:J Pharm Biomed Anal
Glavni autori: Winchester, Lee C., Podany, Anthony T., Baldwin, Joshua S., Robbins, Brian L., Fletcher, Courtney V.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557789/
https://ncbi.nlm.nih.gov/pubmed/25481085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2014.11.011
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