Combined treatment with a CXCL12 analogue and antibiotics improves survival and neutrophil recruitment and function in murine sepsis

Previous studies demonstrated that the CXCL12 peptide analogue CTCE-0214 (CTCE) has beneficial effects in experimental sepsis induced by caecal ligation and puncture (CLP). We examined the hypothesis that CTCE recruits neutrophils (polymorphonuclear leucocytes; PMN) to the site of infection, enhance...

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Publicat a:Immunology
Autors principals: Guan, Shuwen, Guo, Changrun, Zingarelli, Basilia, Wang, Liping, Halushka, Perry V, Cook, James A, Fan, Hongkuan
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557677/
https://ncbi.nlm.nih.gov/pubmed/25201453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12382
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