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The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics

DNA intercalators are widely used as fluorescent probes to visualize DNA and DNA transactions in vivo and in vitro. It is well known that they perturb DNA structure and stability, which can in turn influence DNA-processing by proteins. Here we elucidate this perturbation by combining single-dye fluo...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Biebricher, Andreas S., Heller, Iddo, Roijmans, Roel F. H., Hoekstra, Tjalle P., Peterman, Erwin J. G., Wuite, Gijs J. L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557362/
https://ncbi.nlm.nih.gov/pubmed/26084388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8304
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