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The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics

DNA intercalators are widely used as fluorescent probes to visualize DNA and DNA transactions in vivo and in vitro. It is well known that they perturb DNA structure and stability, which can in turn influence DNA-processing by proteins. Here we elucidate this perturbation by combining single-dye fluo...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Biebricher, Andreas S., Heller, Iddo, Roijmans, Roel F. H., Hoekstra, Tjalle P., Peterman, Erwin J. G., Wuite, Gijs J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557362/
https://ncbi.nlm.nih.gov/pubmed/26084388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8304
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