Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help

CD8(+) T cells activated without CD4(+) T-cell help are impaired in memory expansion. To understand the underlying cellular mechanism, here we track the dynamics of helper-deficient CD8(+) T-cell response to a minor histocompatibility antigen by phenotypic and in vivo imaging analyses. Helper-defici...

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Publicat a:Nat Commun
Autors principals: Kim, Juhyun, Jeong Ryu, Su, Oh, Keunhee, Ju, Ji-Min, Yeong Jeon, Ji, Nam, Giri, Lee, Dong-Sup, Kim, Hang-Rae, Young Kim, Joo, Chang, Jun, Sproule, Thomas, Choi, Kyungho, Roopenian, Derry, Young Choi, Eun
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557278/
https://ncbi.nlm.nih.gov/pubmed/26272364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8994
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