Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating hormone secretion, insulin resistance and dev...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Hayes, M. Geoffrey, Urbanek, Margrit, Ehrmann, David A., Armstrong, Loren L., Lee, Ji Young, Sisk, Ryan, Karaderi, Tugce, Barber, Thomas M., McCarthy, Mark I., Franks, Stephen, Lindgren, Cecilia M., Welt, Corrine K., Diamanti-Kandarakis, Evanthia, Panidis, Dimitrios, Goodarzi, Mark O., Azziz, Ricardo, Zhang, Yi, James, Roland G., Olivier, Michael, Kissebah, Ahmed H., Stener-Victorin, Elisabet, Legro, Richard S., Dunaif, Andrea
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557132/
https://ncbi.nlm.nih.gov/pubmed/26284813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8502
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