Tet-mediated imprinting erasure in H19 locus following reprogramming of spermatogonial stem cells to induced pluripotent stem cells

Selective methylation of CpG islands at imprinting control regions (ICR) determines the monoparental expression of a subset of genes. Currently, it is unclear whether artificial reprogramming induced by the expression of Yamanaka factors disrupts these marks and whether cell type of origin affects t...

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Pubblicato in:Sci Rep
Autori principali: Bermejo-Álvarez, P., Ramos-Ibeas, P., Park, K.E., Powell, A. P., Vansandt, L., Derek, Bickhart, Ramirez, M. A., Gutiérrez-Adán, A., Telugu, B. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556992/
https://ncbi.nlm.nih.gov/pubmed/26328763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13691
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