Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes.

Ontogenic relationships between the different types of endocrine cells in the islets of Langerhans were explored by generating transgenic mouse embryos in which cells transcribing the glucagon, insulin, or pancreatic polypeptide genes were destroyed through the promoter-targeted expression of the di...

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Autori principali: Herrera, P L, Huarte, J, Zufferey, R, Nichols, A, Mermillod, B, Philippe, J, Muniesa, P, Sanvito, F, Orci, L, Vassalli, J D
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1994
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC45568/
https://ncbi.nlm.nih.gov/pubmed/7809163
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