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Are Quasi-Steady-State Approximated Models Suitable for Quantifying Intrinsic Noise Accurately?

Large gene regulatory networks (GRN) are often modeled with quasi-steady-state approximation (QSSA) to reduce the huge computational time required for intrinsic noise quantification using Gillespie stochastic simulation algorithm (SSA). However, the question still remains whether the stochastic QSSA...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sengupta, Dola, Kar, Sandip
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556639/
https://ncbi.nlm.nih.gov/pubmed/26327626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136668
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