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Mechanism of inhibition of mouse Slo3 (K(Ca)5.1) potassium channels by quinine, quinidine and barium

BACKGROUND AND PURPOSE: The Slo3 (K(Ca)5.1) channel is a major component of mammalian KSper (sperm potassium conductance) channels and inhibition of these channels by quinine and barium alters sperm motility. The aim of this investigation was to determine the mechanism by which these drugs inhibit S...

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Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Wrighton, David C, Muench, Stephen P, Lippiat, Jonathan D
Format: Artigo
Langue:Inglês
Publié: John Wiley & Sons, Ltd 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556473/
https://ncbi.nlm.nih.gov/pubmed/26045093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13214
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