Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by which these are affected in NAFLD are not fully understood. The aim is to perform a metabolomic, molecular and epigenetic analyses...

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Pubblicato in:PLoS One
Autori principali: Pacana, Tommy, Cazanave, Sophie, Verdianelli, Aurora, Patel, Vaishali, Min, Hae-Ki, Mirshahi, Faridoddin, Quinlivan, Eoin, Sanyal, Arun J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556375/
https://ncbi.nlm.nih.gov/pubmed/26322888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136822
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