Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by which these are affected in NAFLD are not fully understood. The aim is to perform a metabolomic, molecular and epigenetic analyses...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pacana, Tommy, Cazanave, Sophie, Verdianelli, Aurora, Patel, Vaishali, Min, Hae-Ki, Mirshahi, Faridoddin, Quinlivan, Eoin, Sanyal, Arun J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556375/
https://ncbi.nlm.nih.gov/pubmed/26322888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136822
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