Cyclodextrin Alters GABAergic Input to CA1 Pyramidal Cells in Wild-Type But Not in NPC1-Deficient Mice

Niemann–Pick type C1 disease (NPC1) is a neurodegenerative disorder caused by mutations in the NPC1 gene. Actual, no causative treatment for NPC1 is available, although some drugs have been proven to be beneficial to patients, for example, 2-hydroxypropyl-β-cyclodextrin (CDX). In this study, we used...

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Bibliographic Details
Published in:Biores Open Access
Main Authors: Frech, Moritz J., Rabenstein, Michael, Bovensiepen, Katja, Rost, Sebastian, Rolfs, Arndt
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2015
Subjects:
Brief Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556338/
https://ncbi.nlm.nih.gov/pubmed/26392920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/biores.2015.0023
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