Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay

Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA have suggested that CYP enzyme induction can be measured by both enzymatic activity and mRNA expression. H...

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Pubblicato in:Biomol Ther (Seoul)
Autori principali: Kim, Young-Hoon, Bae, Young-Ji, Kim, Hyung Soo, Cha, Hey-Jin, Yun, Jae-Suk, Shin, Ji-Soon, Seong, Won-Keun, Lee, Yong-Moon, Han, Kyoung-Moon
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Korean Society of Applied Pharmacology 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556210/
https://ncbi.nlm.nih.gov/pubmed/26336590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2015.041
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