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Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies
BACKGROUND: Mutations in the cone-rod-homeobox protein CRX are typically associated with dominant blinding retinopathies with variable age of onset and severity. Five well-characterized mouse models carrying different Crx mutations show a wide range of disease phenotypes. To determine if the phenoty...
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| Publié dans: | Genome Biol |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4556057/ https://ncbi.nlm.nih.gov/pubmed/26324254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0732-z |
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