Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies

BACKGROUND: Mutations in the cone-rod-homeobox protein CRX are typically associated with dominant blinding retinopathies with variable age of onset and severity. Five well-characterized mouse models carrying different Crx mutations show a wide range of disease phenotypes. To determine if the phenoty...

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Bibliographic Details
Published in:Genome Biol
Main Authors: Ruzycki, Philip A., Tran, Nicholas M., Kefalov, Vladimir J., Kolesnikov, Alexander V., Chen, Shiming
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556057/
https://ncbi.nlm.nih.gov/pubmed/26324254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0732-z
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