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Antagonists of PD-1 and PD-L1 in Cancer Treatment
The PD-1 pathway, comprising the immune cell co-receptor Programmed Death 1 (PD-1) and its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), mediates local immunosuppression in the tumor microenvironment. Drugs designed to block PD-1 or PD-L1 “release the brakes” on anti-tumor immunity and have demonstrated...
Shranjeno v:
| izdano v: | Semin Oncol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4555873/ https://ncbi.nlm.nih.gov/pubmed/26320063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.seminoncol.2015.05.013 |
| Oznake: |
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