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Antagonists of PD-1 and PD-L1 in Cancer Treatment

The PD-1 pathway, comprising the immune cell co-receptor Programmed Death 1 (PD-1) and its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), mediates local immunosuppression in the tumor microenvironment. Drugs designed to block PD-1 or PD-L1 “release the brakes” on anti-tumor immunity and have demonstrated...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Semin Oncol
Prif Awduron: Lipson, Evan J., Forde, Patrick M., Hammers, Hans-Joerg, Emens, Leisha A., Taube, Janis M., Topalian, Suzanne L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555873/
https://ncbi.nlm.nih.gov/pubmed/26320063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.seminoncol.2015.05.013
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