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Direct Chemical Activation of a Rationally Engineered Signaling Enzyme
Few chemical strategies for activating enzymes have been developed. Here we show that a biarsenical compound (FlAsH) can directly activate a rationally engineered protein tyrosine phosphatase (Shp2 PTP) via disruption of autoinhibitory interactions between Shp2’s N-terminal SH2 domain and its PTP do...
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| Publié dans: | Chembiochem |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4554683/ https://ncbi.nlm.nih.gov/pubmed/26063205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500245 |
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