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New developments in atherosclerosis: clinical potential of PCSK9 inhibition
Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is a secreted 692-amino acid protein that binds surface low-density lipoprotein (LDL) receptor (LDLR) and targets it toward lysosomal degradation. As a consequence, the number of LDLRs at the cell surface is decreased, and LDL-cholesterol (LDL-C...
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| Publicado no: | Vasc Health Risk Manag |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4554462/ https://ncbi.nlm.nih.gov/pubmed/26345307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/VHRM.S74692 |
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