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The Influenza M2 Cytoplasmic Tail Changes the Proton-Exchange Equilibria and the Backbone Conformation of the Transmembrane Histidine Residue to Facilitate Proton Conduction

The influenza M2 protein forms an acid-activated tetrameric proton channel important for the virus lifecycle. Residue His37 in the transmembrane domain is responsible for channel activation and proton selectivity. While the structure and dynamics of His37 have been well studied in TM peptide constru...

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Publicat a:J Am Chem Soc
Autors principals: Liao, Shu Y., Yang, Yu, Tietze, Daniel, Hong, Mei
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554341/
https://ncbi.nlm.nih.gov/pubmed/25892574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b02510
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