Biologically active LIL proteins built with minimal chemical diversity

We have constructed 26-amino acid transmembrane proteins that specifically transform cells but consist of only two different amino acids. Most proteins are long polymers of amino acids with 20 or more chemically distinct side-chains. The artificial transmembrane proteins reported here are the simple...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Heim, Erin N., Marston, Jez L., Federman, Ross S., Edwards, Anne P. B., Karabadzhak, Alexander G., Petti, Lisa M., Engelman, Donald M., DiMaio, Daniel
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553812/
https://ncbi.nlm.nih.gov/pubmed/26261320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514230112
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