Dimerization of elongator protein 1 is essential for Elongator complex assembly

The evolutionarily conserved Elongator complex, which is composed of six subunits elongator protein 1 (Elp1 to -6), plays vital roles in gene regulation. The molecular hallmark of familial dysautonomia (FD) is the splicing mutation of Elp1 [also known as IκB kinase complex-associated protein (IKAP)]...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Xu, Huisha, Lin, Zhijie, Li, Fengzhi, Diao, Wentao, Dong, Chunming, Zhou, Hao, Xie, Xingqiao, Wang, Zheng, Shen, Yuequan, Long, Jiafu
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553795/
https://ncbi.nlm.nih.gov/pubmed/26261306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502597112
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items