Dimerization of elongator protein 1 is essential for Elongator complex assembly

The evolutionarily conserved Elongator complex, which is composed of six subunits elongator protein 1 (Elp1 to -6), plays vital roles in gene regulation. The molecular hallmark of familial dysautonomia (FD) is the splicing mutation of Elp1 [also known as IκB kinase complex-associated protein (IKAP)]...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Xu, Huisha, Lin, Zhijie, Li, Fengzhi, Diao, Wentao, Dong, Chunming, Zhou, Hao, Xie, Xingqiao, Wang, Zheng, Shen, Yuequan, Long, Jiafu
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553795/
https://ncbi.nlm.nih.gov/pubmed/26261306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502597112
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