The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

Efficient apoptotic cell clearance and induction of immunologic tolerance is a critical mechanism preventing autoimmunity and associated pathology. Our laboratory has reported that apoptotic cells induce tolerance by a mechanism dependent on the tryptophan catabolizing enzyme indoleamine 2,3 dioxyge...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Ravishankar, Buvana, Liu, Haiyun, Shinde, Rahul, Chaudhary, Kapil, Xiao, Wei, Bradley, Jillian, Koritzinsky, Marianne, Madaio, Michael P., McGaha, Tracy L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553766/
https://ncbi.nlm.nih.gov/pubmed/26261340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504276112
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