Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy

Inflammatory kidney disease is a major clinical problem that can result in end-stage renal failure. Here we show that antibody mediated inflammatory kidney injury and renal disease in a mouse nephrotoxic serum nephritis (NTN) model was inhibited by amino acid metabolism and a protective autophagic r...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Chaudhary, Kapil, Shinde, Rahul, Liu, Haiyun, Gnana-Prakasam, Jaya P., Veeranan-Karmegam, Rajalakshmi, Huang, Lei, Ravishankar, Buvana, Bradley, Jillian, Kvirkvelia, Nino, McManamin, Malgorzata, Xiao, Wei, Kleven, Daniel, Mellor, Andrew L., Madaio, Michael P., McGaha, Tracy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458436/
https://ncbi.nlm.nih.gov/pubmed/25980011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500277
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