Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations

OBJECTIVES: The objective of this study was to characterize the underlying molecular mechanisms in consecutive clinical Candida albicans isolates from a single patient displaying stepwise-acquired multidrug resistance. METHODS: Nine clinical isolates (P-1 to P-9) were susceptibility tested by EUCAST...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Jensen, Rasmus Hare, Astvad, Karen Marie Thyssen, Silva, Luis Vale, Sanglard, Dominique, Jørgensen, Rene, Nielsen, Kristian Fog, Mathiasen, Estella Glintborg, Doroudian, Ghazalel, Perlin, David Scott, Arendrup, Maiken Cavling
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553713/
https://ncbi.nlm.nih.gov/pubmed/26017038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv140
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