Amyloid-β (11)C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials

OBJECTIVE: To evaluate the effects of bapineuzumab on brain β-amyloid (Aβ) burden using (11)C-Pittsburgh compound B ((11)C-PiB)-PET. METHODS: Two phase 3 clinical trials, 1 each in apolipoprotein APOE ε4 carriers and noncarriers, were conducted in patients with mild to moderate Alzheimer disease dem...

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Udgivet i:Neurology
Main Authors: Liu, Enchi, Schmidt, Mark E., Margolin, Richard, Sperling, Reisa, Koeppe, Robert, Mason, Neale S., Klunk, William E., Mathis, Chester A., Salloway, Stephen, Fox, Nick C., Hill, Derek L., Les, Andrea S., Collins, Peter, Gregg, Keith M., Di, Jianing, Lu, Yuan, Tudor, I. Cristina, Wyman, Bradley T., Booth, Kevin, Broome, Stephanie, Yuen, Eric, Grundman, Michael, Brashear, H. Robert
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553028/
https://ncbi.nlm.nih.gov/pubmed/26208959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000001877
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