Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma.

A transgenic mouse strain that expresses the hepatitis B virus (HBV) large envelope protein in the liver was used to determine the extent of oxidative DNA damage that occurs during chronic HBV infection. This mouse strain develops a chronic necroinflammatory liver disease that mimics the inflammatio...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Hagen, T M, Huang, S, Curnutte, J, Fowler, P, Martinez, V, Wehr, C M, Ames, B N, Chisari, F V
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1994
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45529/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7809125/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.12808
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