DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection

There is an urgent need for effective prophylactic measures against Mycobacterium tuberculosis (Mtb) infection, particularly given the highly variable efficacy of Bacille Calmette-Guerin (BCG), the only licensed vaccine against tuberculosis (TB). Most studies indicate that cell-mediated immune respo...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Dalmia, Neha, Klimstra, William B., Mason, Carol, Ramsay, Alistair J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552820/
https://ncbi.nlm.nih.gov/pubmed/26317509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136635
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