Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease.

X-linked agammaglobulinemia (XLA) is a hereditary defect of B-cell differentiation in man caused by deficiency of Bruton tyrosine kinase (BTK). A three-dimensional model for the BTK kinase domain, based on the core structure of cAMP-dependent protein kinase, was used to interpret the structural basi...

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Bibliografiske detaljer
Main Authors: Vihinen, M, Vetrie, D, Maniar, H S, Ochs, H D, Zhu, Q, Vorechovský, I, Webster, A D, Notarangelo, L D, Nilsson, L, Sowadski, J M
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC45528/
https://ncbi.nlm.nih.gov/pubmed/7809124
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