Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease.
X-linked agammaglobulinemia (XLA) is a hereditary defect of B-cell differentiation in man caused by deficiency of Bruton tyrosine kinase (BTK). A three-dimensional model for the BTK kinase domain, based on the core structure of cAMP-dependent protein kinase, was used to interpret the structural basi...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1994
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45528/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7809124/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.12803 |
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