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Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease.

X-linked agammaglobulinemia (XLA) is a hereditary defect of B-cell differentiation in man caused by deficiency of Bruton tyrosine kinase (BTK). A three-dimensional model for the BTK kinase domain, based on the core structure of cAMP-dependent protein kinase, was used to interpret the structural basi...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Vihinen, M, Vetrie, D, Maniar, H S, Ochs, H D, Zhu, Q, Vorechovský, I, Webster, A D, Notarangelo, L D, Nilsson, L, Sowadski, J M
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1994
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45528/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7809124/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.12803
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