Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors

HIV-1 Vpu prevents incorporation of tetherin (BST2/ CD317) into budding virions and targets it for ESCRT-dependent endosomal degradation via a clathrin-dependent process. This requires a variant acidic dileucine-sorting motif (ExxxLV) in Vpu. Structural studies demonstrate that recombinant Vpu/tethe...

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Detaylı Bibliyografya
Yayımlandı:PLoS Pathog
Asıl Yazarlar: Kueck, Tonya, Foster, Toshana L., Weinelt, Julia, Sumner, Jonathan C., Pickering, Suzanne, Neil, Stuart J. D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552633/
https://ncbi.nlm.nih.gov/pubmed/26317613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005141
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