The mixed-action delta/mu opioid agonst MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

Previous work in our laboratories provides preclinical evidence that mixed-action delta/mu receptor glycopeptides have equivalent efficacy for treating pain with reduced side effect profiles compared to widely used mu agonist analgesics such as morphine. This study evaluated the rewarding and reinfo...

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Bibliografske podrobnosti
izdano v:Pharmacol Biochem Behav
Main Authors: Stevenson, Glenn W., Luginbuhl, Amy, Dunbar, Catherine, LaVigne, Justin, Dutra, Julio, Atherton, Phillip, Bell, Brooke, Cone, Katherine, Giuvelis, Denise, Polt, Robin, Streicher, John M., Bilsky, Edward J.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552603/
https://ncbi.nlm.nih.gov/pubmed/25735493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2015.02.022
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