Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

Human leukocyte antigen (HLA) genes confer strong risk for autoimmune diseases on a log-additive scale. Here we speculated that differences in autoantigen binding repertoires between a heterozygote’s two expressed HLA variants may result in additional non-additive risk effects. We tested non-additiv...

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Gepubliceerd in:Nat Genet
Hoofdauteurs: Lenz, Tobias L., Deutsch, Aaron J., Han, Buhm, Hu, Xinli, Okada, Yukinori, Eyre, Stephen, Knapp, Michael, Zhernakova, Alexandra, Huizinga, Tom W.J., Abecasis, Goncalo, Becker, Jessica, Boeckxstaens, Guy E., Chen, Wei-Min, Franke, Andre, Gladman, Dafna D., Gockel, Ines, Gutierrez-Achury, Javier, Martin, Javier, Nair, Rajan P., Nöthen, Markus M., Onengut-Gumuscu, Suna, Rahman, Proton, Rantapää-Dahlqvist, Solbritt, Stuart, Philip E., Tsoi, Lam C., Van Heel, David A., Worthington, Jane, Wouters, Mira M., Klareskog, Lars, Elder, James T., Gregersen, Peter K., Schumacher, Johannes, Rich, Stephen S., Wijmenga, Cisca, Sunyaev, Shamil R., de Bakker, Paul I.W., Raychaudhuri, Soumya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552599/
https://ncbi.nlm.nih.gov/pubmed/26258845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3379
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