Removal of H2A.Z by INO80 promotes homologous recombination

The mammalian INO80 remodelling complex facilitates homologous recombination (HR), but the mechanism by which it does this is unclear. Budding yeast INO80 can remove H2A.Z/H2B dimers from chromatin and replace them with H2A/H2B dimers. H2A.Z is actively incorporated at sites of damage in mammalian c...

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Bibliographic Details
Published in:EMBO Rep
Main Authors: Alatwi, Hanan E, Downs, Jessica A
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2015
Subjects:
Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552491/
https://ncbi.nlm.nih.gov/pubmed/26142279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201540330
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