Exploration of hydroxymethylation in Kagami-Ogata syndrome caused by hypermethylation of imprinting control regions

BACKGROUND: 5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytosine (5mC) by ten-eleven translocation (Tet) enzymes, has recently drawn attention as the “sixth base” of DNA since it is considered an intermediate of the demethylation pathway. Nonetheless, it remains to be addressed how 5hmC i...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Matsubara, Keiko, Kagami, Masayo, Nakabayashi, Kazuhiko, Hata, Kenichiro, Fukami, Maki, Ogata, Tsutomu, Yamazawa, Kazuki
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552283/
https://ncbi.nlm.nih.gov/pubmed/26322139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0124-y
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