KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis

Herein we employ Myh11-CreER(T2) ROSA floxed STOP eYFP Apoe(−/−) smooth muscle cell (SMC) lineage tracing mice to show that traditional methods for detecting SMCs based on immuno-staining fail to detect > 80% of SMC-derived cells within advanced atherosclerotic lesions. These unidentified SMC-der...

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Bibliografiska uppgifter
I publikationen:Nat Med
Huvudupphovsmän: Shankman, Laura S., Gomez, Delphine, Cherepanova, Olga A., Salmon, Morgan, Alencar, Gabriel F., Haskins, Ryan M., Swiatlowska, Pamela, Newman, Alexandra A. C., Greene, Elizabeth S., Straub, Adam C., Isakson, Brant, Randolph, Gwendalyn J., Owens, Gary K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552085/
https://ncbi.nlm.nih.gov/pubmed/25985364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3866
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