Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR(-/-)) Mice

OBJECTIVE: Atherosclerosis, a chronic inflammatory disease, arises from metabolic disorders and is driven by inappropriate recruitment and proliferation of monocytes / macrophages and vascular smooth-muscle-cells. The receptor for the urokinase-type plasminogen activator (uPAR, Plaur) regulates the...

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Pubblicato in:PLoS One
Autori principali: Larmann, Jan, Jurk, Kerstin, Janssen, Henrike, Müller, Martin, Herzog, Christine, Lorenz, Anika, Schmitz, Martina, Nofer, Jerzy-Roch, Theilmeier, Gregor
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551736/
https://ncbi.nlm.nih.gov/pubmed/26313756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131854
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