IL-10 from marginal zone precursor B cell subset is required for costimulatory blockade induced transplantation tolerance

BACKGROUND: Blocking CD40-CD40L costimulatory signals induces transplantation tolerance. While B cell depletion prevents alloantibody formation, non-humoral functions of B cells in tolerance have not been well characterized. We investigated whether specific subsets of B cell or B cell derived IL-10...

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Detalhes bibliográficos
Publicado no:Transplantation
Main Authors: Lal, Girdhari, Nakayama, Yumi, Sethi, Apoorva, Singh, Amit K., Burrell, Bryna E, Kulkarni, Neeraja, Brinkman, C. Colin, Iwami, Daiki, Zhang, Tianshu, Bromberg, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551603/
https://ncbi.nlm.nih.gov/pubmed/25839706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000000718
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