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Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

Activation of the NF-kappa B/Rel family of transcription factors is regulated by a cytoplasmic inhibitor, I kappa B alpha. Activity of I kappa B alpha is in turn modulated by phosphorylation and proteolysis. It has been postulated that phosphorylation of I kappa B alpha leads to its dissociation fro...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Miyamoto, S, Maki, M, Schmitt, M J, Hatanaka, M, Verma, I M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45515/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7809113/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.12740
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