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Bruton's Tyrosine Kinase Synergizes with Notch2 to Govern Marginal Zone B Cells in Nonobese Diabetic Mice(,)
Expansion of autoimmune-prone marginal zone (MZ) B cells has been implicated in type 1 diabetes (T1D). To test disease contributions of MZ B cells in NOD mice, Notch2 haploinsufficiency (Notch2(+/−)) was introduced, but failed to eliminate the MZ, as it does in C57BL/6 mice. Notch2(+/−)/NOD have MZ...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551465/ https://ncbi.nlm.nih.gov/pubmed/26034172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400803 |
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