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Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds

As multiple myeloma (MM) progresses, natural killer (NK)-cell responses decline against malignant plasma cells. The immunomodulatory drug lenalidomide is widely used for treatment of MM but its influence on NK-cell biology is unclear. Here, we report that lenalidomide lowers the threshold for NK-cel...

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Pubblicato in:Blood
Autori principali: Lagrue, Kathryn, Carisey, Alex, Morgan, David J., Chopra, Rajesh, Davis, Daniel M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551357/
https://ncbi.nlm.nih.gov/pubmed/26002964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-625004
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