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Depletion of the Polyamines Spermidine and Spermine by Overexpression of Spermidine/spermine N(1)-Acetyltransferase1 (SAT1) Leads to Mitochondria-Mediated Apoptosis in Mammalian Cells
The polyamines putrescine, spermidine and spermine are intimately involved in the regulation of cellular growth and viability. Transduction of HEK293T cells with an adenovirus (AdSAT1) encoding a key polyamine catabolic enzyme, spermidine/spermine N(1)-acetyltransferase1 (SAT1), leads to a rapid dep...
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| Publicado no: | Biochem J |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4550555/ https://ncbi.nlm.nih.gov/pubmed/25849284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150168 |
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