Depletion of the Polyamines Spermidine and Spermine by Overexpression of Spermidine/spermine N(1)-Acetyltransferase1 (SAT1) Leads to Mitochondria-Mediated Apoptosis in Mammalian Cells

The polyamines putrescine, spermidine and spermine are intimately involved in the regulation of cellular growth and viability. Transduction of HEK293T cells with an adenovirus (AdSAT1) encoding a key polyamine catabolic enzyme, spermidine/spermine N(1)-acetyltransferase1 (SAT1), leads to a rapid dep...

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Udgivet i:Biochem J
Main Authors: Mandal, Swati, Mandal, Ajeet, Park, Myung Hee
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550555/
https://ncbi.nlm.nih.gov/pubmed/25849284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150168
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