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Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells
The polyamines, putrescine, spermidine, and spermine, are essential polycations, intimately involved in the regulation of cellular proliferation. Although polyamines exert dynamic effects on the conformation of nucleic acids and macromolecular synthesis in vitro, their specific functions in vivo are...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568356/ https://ncbi.nlm.nih.gov/pubmed/23345430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219002110 |
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